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1 edition of Apoptosis in the pathogenesis and treatment of disease found in the catalog.

Apoptosis in the pathogenesis and treatment of disease

Apoptosis in the pathogenesis and treatment of disease

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Published by Springer in Heidelberg, Germany .
Written in English

    Subjects:
  • Apoptosis -- Therapeutic use.,
  • Apoptosis -- Pathogenesis.

  • Edition Notes

    Statementguest editor, David L. Vaux.
    SeriesSpringer seminars in immunopathology -- v. 19, no. 3.
    ContributionsVaux, David L.
    The Physical Object
    Paginationp. [271]-362 :
    Number of Pages362
    ID Numbers
    Open LibraryOL15534426M


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Apoptosis in the pathogenesis and treatment of disease Download PDF EPUB FB2

Apoptosis in the Pathogenesis and Treatment of Disease Craig B. Thompson In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death.

Although much is known about the control of cell proliferation, less is known about the control of cell death. Physiologic cell death occurs primarily. In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death.

Although much is known about the control of cell proliferation, less is known about the control of cell death. Physiologic cell death occurs primarily through an evolutionarily conserved form of cell suicide termed apoptosis. The decision of a cell to undergo apoptosis can be Cited by: The decision of a cell to undergo apoptosis can be influenced by a wide variety of regulatory stimuli.

Recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency Cited by:   In adult multicellular organisms, homeostasis is determined in each cell lineage by a balance between cell death and cell growth.

Dysregulation of cell death mechanisms is involved in the pathogenesis of an increasing number of diseases. Defective apoptosis can participate in malignant transformation, viral latency and autoimmune by: Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions.

It is also one of the most studied topics among cell biologists. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of Apoptosis in the pathogenesis and treatment of disease book by: The failure of cells to undergo apoptosis might be involved in the pathogenesis of several human prolifer-ative disorders characterized by the accumulation of cells, including cancer, autoimmune diseases and certain viral infections (fig.

Apoptosis and cancer. Cancer is usually envisaged as a disease of excessive cellular proliferation. The past few years have seen rapid progress in apoptosis research. This volume deals with many of the recent advances made in uncovering the molecular and cellular basis of apoptosis and elaborates on how this accumulating knowledge is helping us to understand the significance of apoptosis in pathogenesis of diseases arising from inappropriate cell death.

DOI: / Corpus ID: The role of apoptosis in the pathogenesis and treatment of diseases. @article{SolaryTheRO, title={The role of apoptosis in the pathogenesis and treatment of diseases.}, author={Eric Solary and L Dubrez and B{\'e}atrice Eymin}, journal={The European respiratory journal}, year={}, volume={9 6}, pages={ } }.

The decision of a cell to undergo apoptosis can be influenced by a wide variety of regulatory stimuli. Recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency.

This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic.

In addition, the book covers the tools and techniques used to quantify apoptosis and the Apoptosis in the pathogenesis and treatment of disease book of apoptosis in drug discovery, drug delivery, and its applications in disease prevention.

Finally, the book provides a comprehensive compilation of the apoptosis. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists.

An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. In some, the problem is due to too much apoptosis, such as in the Cited by: Keywords:apoptosis, autoimmune disease, bcl, bcl-xl, granzyme b.

Abstract: Apoptosis is a physiological mechanism of cell death. Defects in the apoptosis machinery may lead to serious disease such as: autoimmune disease, cancer, drug resistance in tumors, and the acquired immunodeficiency syndrome (AIDS).

In this article, bone cells and their intercellular communications have been reviewed. Gap junctions and hemichannels are the main routes of interactions in bone tissue. They play a substantial role in survival and cell death, since pro-apoptotic signals can propagate through them.

Different adhesion molecules are required for apoptosis, particularly caspase family as well as noncaspase Cited by: Cambridge Core - Pathology and Laboratory Science - Apoptosis in Health and Disease - edited by Martin Holcik.

Role of apoptosis in pathogenesis and treatment of bone-related diseases Samaneh Mollazadeh1, Bibi Sedigheh Fazly Bazzaz2 and Mohammad Amin Kerachian3,4* Abstract In this article, bone cells and their intercellular communications have been reviewed.

Gap junctions and hemichannels are the main routes of interactions in bone tissue. Apoptosis plays an important role in many developmental processes and contributes to cell and tissue homeostasis.

Induction of apoptosis can involve the “intrinsic pathway”, which is activated by diverse stress signals, and the “extrinsic pathway”, which is activated by proapoptotic receptor signals at the cell surface.

Excessive or aberrant apoptosis is a crucial factor in many human Cited by: 7. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy PDF Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy PDF Free Download, Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy PDF, Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy Ebook Content This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment.

Endometriosis is one of the most common gynecological diseases, causing pelvic pain, infertility, and cancer. The condition reduces the quality of life for the estimated 10% of menstruating women who are affected by it.

This book provides a clear insight into the pathogenesis and pathophysiology of endometriosis—essential information for clinicians intending to successfully treat.

The second pattern is apoptosis, a form of programmed cell death. Acute and Chronic Inflammation Induces Disease Pathogenesis. Catherine Ptaschinski and Nicholas W.

Lukacs characterization of the steps of gastrointestinal neoplastic development and progression has led to advances in disease diagnosis and treatment and has opened the. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease: Part V.

Oxidative Stress and Apoptosis Mitochondrial DNA Mutation and Depletion Increase the Susceptibility of Human Cells to Apoptosis. Apoptosis in cancer: from pathogenesis to treatment Rebecca SY Wong Abstract Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions.

It is also one of the most studied topics among cell biologists. An understanding of. #### Summary points Apoptosis is a genetically regulated form of cell death It has a role in biological processes, including embryogenesis, ageing, and many diseases The molecular mechanisms involved in death signals, genetic regulation, activation of effectors have been identified Many existing treatments (such as non-steroidal anti.

Apoptosis is the process by which single cells die in the midst of living tissues. It is responsible for most—perhaps all—of the cell-death events that occur during the formation of the early embryo and the sculpting and moulding of organs. Apoptotic cell death continues to play a critical role in the maintenance of cell numbers in those tissues in which cell turnover persists into adult.

This book takes account of the most recent findings in laboratory research and clinical trials to provide a comprehensive and up-to-date reference on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. As well as providing a detailed overview of the pathophysiology of the disease, the international team of authors covers all aspects of.

Endometriosis is one of the most common gynecological diseases, causing pelvic pain, infertility, and cancer.

The condition reduces the quality of life for the estimated 10% of menstruating women who are affected by it.

This book provides a clear insight into the pathogenesis and pathophysiology of. Induction of apoptosis can involve the "intrinsic pathway", which is activated by diverse stress signals, and the "extrinsic pathway", which is activated by proapoptotic receptor signals at the cell surface.

Excessive or aberrant apoptosis is a crucial factor in many human disorders, including polycystic kidney disease (PKD).Cited by: 7.

Endothelial apoptosis can be found in a number of diseases. This review summarizes the current knowledge about the causes and consequences of endothelial apoptosis, and analyzes its possible role in the pathogenesis and treatment of several diseases. Novel forms of therapy based on the proposed pathophysiologic mechanisms are discussed.

pathogenesis of poliomyelitis, and then consider several models of PV- induced apoptosis; we w ill also address the role of the cellular receptor of PV, CD, in the modulation of apoptosis. In this chapter, we will examine how inappropriate or excessive apoptosis can lead to autoimmune disorders, such as type I diabetes, autoimmune thyroid disease, rheumatoid arthritis, lupus and others.

Furthermore, we present data demonstrating that apoptosis-related treatments can be effective against various autoimmune disorders. Abstract:Apoptosis is a rare event in normal hepatocytes. However, multiple signals can trigger apoptosis in hepatocytes and it plays a role in the pathogenesis of many liver diseases.

This review summarizes the mechanisms of hepatocellular apoptosis and the importance of apoptosis in the pathological processes of liver disease. In light of the considerable prevalence of NAFLD and its associated increased mortality, there is a pressing need for identifying effective treatments for this disease.

The pathogenesis of NAFLD is multifactorial, involving obesity, insulin resistance, inflammation, oxidative stress and increased hepatocyte apoptosis[8,12]. Get this from a library. Mitochondrial pathogenesis: from genes and apoptosis to aging and disease.

[Hong Kyu Lee; Asian Society for Mitochondrial Research and Medicine. Scientific Meeting]. Ovarian cancer is the leading cause of death from gynecologic malignancies yet the underlying pathophysiology is not clearly established. Epithelial ovarian cancer (EOC) has long been considered a heterogeneous disease with respect to histopathology, molecular biology, and clinical outcome.

Treatment of ovarian cancer includes a combination of cytoreductive surgery and. Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease (Annals of the New York Academy of Sciences ()) [Lee, Hong Kyu, DiMauro, Salvatore, Tanaka, Masashi, Wei, Yau-Huei] on *FREE* shipping on qualifying offers.

Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease (Annals of the New York Academy of Sciences ()). For this Special Issue of Biomolecules, “Cell Death in Cancer and Inflammation: From Pathogenesis to Treatment”, we encourage the submission of review and primary research articles that showcase both the role of cell death and therapeutic approaches targeting cell death pathways in cancer and inflammation.

Ivan Poon Dr. Georgia Atkin-Smith. OBJECTIVE: To review the current state of knowledge of apoptosis, with an emphasis on identifying potential and established roles for apoptosis in the pathogenesis of infectious SOURCES: MEDLINE and the University of British Columbia library system were searched using the search subject, “apoptosis”, for the years to based on etiology, pathogenesis and histological and ultrastructural appearance.

•Compare and contrast pathologic features and the clinical settings in which necrotic and apoptotic cell death occurs.

•List in temporal order the genetic and biochemical steps in apoptosis. •Contrast and compare physiologic and pathologic apoptosis. Get this from a library. Apoptosis in cancer pathogenesis and anti-cancer therapy: new perspectives and opportunities.

[Christopher D Gregory;] -- This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment.

Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses. Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-weight thiol in mammalian is formed in a two-step enzymatic process including, first, the formation of γ-glutamylcysteine from glutamate and cysteine, by the activity of the γ-glutamylcysteine synthetase; and second, the formation of GSH by the activity of GSH sythetase which uses γ.

Apoptosis is a form of cell death that is claimed to be involved in a number of chronic inflammatory and malignant skin diseases. The aim of this study was to investigate whether apoptosis may contribute to the pathogenesis of epidermal changes in dermatitis herpetiformis (DH) and, in particular, whether certain apoptosis-related markers such.Nonalcoholic steatohepatitis (NASH) represents an advanced stage of fatty liver disease developed in the absence of alcohol abuse.

Its increasing prevalence in western countries, the diagnostic difficulties by noninvasive tests, and the possibility of progression to advanced fibrosis and even cirrhosis make NASH a challenge for hepatologists.In recent years, we have made significant progress in understanding the pathological and genetic basis of Parkinson’s disease and its heterogeneous forms, and the first section of the book is dedicated to reviewing this.

The variable clinical features of Parkinson’s disease and its .